Electroacupuncture
(EA) stimulation at some immune acupoints such as L14, LI11, DU20, DU14, ST36
and LV3 in both humans and rats activated hypothalamus and enhanced sympathetic
nervous system (SNY) function, leading to mobilization of mesenchyals stem
cells (MSC). EA-induced mobilization of circulating MSC increased anti-inflammation
products; markedly reduced pain sensitivity and enhanced tissue repair. The study
was published in journal of Stem Cells recently.
Recently a
collaboration of acupuncture study by many research groups in the United States
investigated the mechanism responsible for the beneficial systemic effects and
healing associated with acupuncture in both humans and models.
First, the fMRI
studies in both humans and models found that EA stimulation at L14, LI11, DU20,
DU14 acupoints increased functional connectivity between the anterior hypothalamus
and the amygdala and mobilized MSC into the systemic circulation. MSC were
characterized as adipocyte-derived MSC in human, whereas, MSC were considered
more heterogeneous in models.
Then, Pharmacological
disinhibition of model hypothalamus by administration of the GABAA receptor antagonist
bicuculline enhanced SNS activation and similarly resulted in a release of MSC
into the circulation.
Finally, in models
with partial rupture of the Achilles tendon, EA stimulation reduced mechanical
hyperalgesia, increased anti-inflammation products such as serum IL‐10 and enhanced tendon remodelling and tissue repair.
The study
suggested that EA may serve as way of facilitating tissue repair following by supplying
high level of circulating MSC into the circulation and could be used to treat
acute or chronic conditions associated with inflammation.
Reference
Salazar TE et al., Electroacupuncture Promotes
CNS-Dependent Release of Mesenchymal Stem Cells. Stem Cells. 2017 Mar 16. doi:
10.1002/stem.2613. https://www.ncbi.nlm.nih.gov/pubmed/28299842
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