Duchenne muscular dystrophy (DMD)
is a genetic disorder characterized
by progressive muscle degeneration and weakness. Chinese medicine including acupuncture, herbs and Tuina
holds potential to help alleviate symptoms and enhance muscle function of
patients with DMD. A team of researchers combined a number of alternative therapies
along with drug therapy to create a treatment regimen for DMD patients. During
the study, the combined treatments resulted in a significant improvement in
physical function and reduced inflammation in the patients’ bodies.
DMD
was initially described by French neurologist Guillaume Benjamin Amand Duchenne
in the 1860s. Research studies identified the chromosomal mutation responsible
for DMD in 1986. This mutation leads to a lack of dystrophin protein in muscle
cells thereby making them fragile. Onset is between ages 3 – 5 and boys are
predominantly affected, and the carrier is the mother because the gene mutation
is X-linked.
The research team enrolled 60
paediatric DMD patients at the Neurology and Rehabilitation Department at
Zhengzhou Children’s Hospital, in China for
a two-year randomized controlled trial.Upon enrolment, patients were divided into combined
treatment and drug-only groups. The combined treatment group received
acupuncture, far infrared therapy, TCM tuina massage, herbal medicine, and drug
therapy, while the drug-only group received drug therapy alone.
Following treatment, patients saw
a total effective rate improvement of 20% in the combined treatment group, including reduced physical
impairments and improvements in both walking and staircase climbing, compared to the drug-only group. Total effective
improvement is calculated using full recovery, significant recovery, and
effective as three parameters of improvement. The calculation led to a total
effective rate improvement of 93.3% in the combined treatment group and 73.3%
in the drug-only group.
In addition, the combined
treatment group experienced significant improvements in enzymes and saw a
reduction in serum inflammatory markers such as creatine phosphokinase (CPK), lactate dehydrogenase (LDH),
and aspartate transaminase (AST).
Enhanced enzyme profiles were indicative of lower inflammation in the combined
treatment group when compared to the drug-only group.
The study showed that the
combination of multiple types of CM with conventional drug treatment
significantly improved physical impairment and reduced in inflammatory related
muscle enzyme secretions. The further study with large size samples is
warranted.
Reference
Meng,
QP (2015). The clinical effects of combining acupuncture and physical therapy
with drugs in treating children with Duchenne muscular dystrophy. Chinese
Journal of Physical Medicine and Rehabilitation 2015; 37(6): 446-448. http://wprim.whocc.org.cn/local/detail.jsp?channelid=75002&searchword=WPRIMID%3D884699
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